A dust-obscured massive maximum-starburst galaxy at a redshift of 6.34.

Massive present-day early-type (elliptical and lenticular) galaxies probably gained the bulk of their stellar mass and heavy elements through intense, dust-enshrouded starbursts--that is, increased rates of star formation--in the most massive dark-matter haloes at early epochs. However, it remains unknown how soon after the Big Bang massive starburst progenitors exist. The measured redshift (z) distribution of dusty, massive starbursts has long been suspected to be biased low in z owing to selection effects, as confirmed by recent findings of systems with redshifts as high as ~5 (refs 2-4). Here we report the identification of a massive starburst galaxy at z = 6.34 through a submillimetre colour-selection technique. We unambiguously determined the redshift from a suite of molecular and atomic fine-structure cooling lines. These measurements reveal a hundred billion solar masses of highly excited, chemically evolved interstellar medium in this galaxy, which constitutes at least 40 per cent of the baryonic mass. A 'maximum starburst' converts the gas into stars at a rate more than 2,000 times that of the Milky Way, a rate among the highest observed at any epoch. Despite the overall downturn in cosmic star formation towards the highest redshifts, it seems that environments mature enough to form the most massive, intense starbursts existed at least as early as 880 million years after the Big Bang.

Sindrome hemofagocitico asociado a EMTC y crisis renal esclerodermica / Hemophagocytic syndrome associated to mixed connective

Una paciente de 63 años con diagnostico de enfermedad mixta del tejido conectivo (polimiositis, esclerosis sistemica progresiva, RNP+) consulta por episodio de lesiones equimoticas en abdomen, manos y pies con plaquetopenia y laboratorio compatible con coagulopatia por consumo. En la puncion de medula osea se encuentra, celularidad disminuida con serie megacariocitica ausente y abundantes macrofagos con fenomemo de hemofagocitosis

Sindrome hemofagocitico asociado a EMTC y crisis renal esclerodermica / Hemophagocytic syndrome associated to mixed connective

Una paciente de 63 años con diagnostico de enfermedad mixta del tejido conectivo (polimiositis, esclerosis sistemica progresiva, RNP+) consulta por episodio de lesiones equimoticas en abdomen, manos y pies con plaquetopenia y laboratorio compatible con coagulopatia por consumo. En la puncion de medula osea se encuentra, celularidad disminuida con serie megacariocitica ausente y abundantes macrofagos con fenomemo de hemofagocitosis (AU)

Matrigel promotes retinoblastoma cell growth in vitro and in vivo.

Cells derived from retinoblastomas grow slowly in vitro and only very rarely form tumors in nude mice. Matrigel, a mixture of components normally found in basement membranes, promotes the growth of Y-79 and WERI-Rb1 retinoblastoma (Rb) cells when added to suspension cultures of the 2 Rb cell lines. It also substantially increases cell adhesion in vitro. Y-79 cells, seeded into a Matrigel matrix, form round colonies over a 3-week period similar to those of control, weakly metastatic murine melanoma cells. In vivo, s.c. co-injection of Matrigel with either Y-79 or WERI-Rb 1 cells into nude mice promotes retinoblastoma tumor formation. Transplantation of as few as 1,000 cells allows for xenografting under these conditions, while no tumors were observed in the absence of Matrigel, even at 10 x 10(6) cells/inoculum. The tumors produced have the expected morphology and express an mRNA for a highly specific retina/retinoblastoma marker protein, the interphotoreceptor retinoid-binding protein. Thus, the xenografts obtained maintain the original morphological and molecular characteristics of the injected cells and represent a useful model for in vivo studies of retinoblastoma growth and treatment.